Systemic Sclerosis / Scleroderma (SScl)
ثبت نشده
چکیده
While it is called by many names and comes in different varieties, SScl is characterized by one basic problem: overproduction of collagen. Collagen is an important protein in the body that is a component of scar tissue, which allows injuries to heal. When too much collagen is deposited, however, a number of problems can arise, and this is the basic obstacle that must be faced in patients with SScl.
منابع مشابه
Cold hands – strained heart? Advances in the management of Raynaud's phenomenon and pulmonary hypertension
Vasculopathy is an increasingly recognised partner to inflammatory rheumatological disease. Raynaud’s phenomenon (RP) is generally considered a benign vascular manifestation. The natural history of systemic sclerosis (SScl), however, suggests that we underestimate the significance of RP in this context. RP occurs in approximately 90% of SScl patients, often decades before the diagnosis is recog...
متن کاملIncreased levels of alternatively spliced interleukin 4 (IL-4delta2) transcripts in peripheral blood mononuclear cells from patients with systemic sclerosis.
Recent in vitro studies have shown that interleukin 4 (IL-4) induces and gamma interferon (IFN-gamma) inhibits collagen production. To define the TH1(IFN-gamma) and TH2(IL-4) cytokine profiles in systemic sclerosis (Sscl), a disease characterized by widespread fibrosis, we investigated IL-4 and IFN-gamma transcripts in peripheral blood mononuclear cells and plasma protein levels in 13 patients ...
متن کامل351 Prevalence of Thyroid Peroxidase Autoantibodies (ANTI-TPO) in Women with Autoimmune Connective Tissue Diseases (ACTD)
351 Prevalence of Thyroid Peroxidase Autoantibodies (ANTI-TPO) in Women with Autoimmune Connective Tissue Diseases (ACTD) Georgios Papadopoulos, MD, Anastasia Vakaloudi, PhD, Eirene Koutsika, MD, Ekarerini Anastasiou, MD, and Asimoula Koteli, MD. Immunology Laboratory, General Hospital Agios Pavlos, Thessaloniki, Greece. Background: Chronic autoimmune thyroiditis, manifested by positive test fo...
متن کاملSystemic Sclerosis (Scleroderma)
labmedicine.com November 2005 Volume 36 Number 11 LABMEDICINE 723 Systemic sclerosis is a chronic disease of unknown etiology characterized by abnormal accumulation of fibrous tissue in the skin and multiple organs.1 Scleroderma derives its name from the Greek words “sclerosis” (hardness) and “derma” (skin), thus aptly named “hard skin,” a feature that is common to all the different types of sc...
متن کامل354 Autoimmune Hepatitis Misdiagnosed as Hepatitis C Responding to Interferon/Ribavirine Therapy
351 Prevalence of Thyroid Peroxidase Autoantibodies (ANTI-TPO) in Women with Autoimmune Connective Tissue Diseases (ACTD) Georgios Papadopoulos, MD, Anastasia Vakaloudi, PhD, Eirene Koutsika, MD, Ekarerini Anastasiou, MD, and Asimoula Koteli, MD. Immunology Laboratory, General Hospital Agios Pavlos, Thessaloniki, Greece. Background: Chronic autoimmune thyroiditis, manifested by positive test fo...
متن کامل